Creative Bioarray has announced the launch of its cell angiogenesis assays, designed to accelerate the discovery and validation of anti-angiogenic therapies in oncology.
— Creative Bioarray, one of the leaders in life science research services, supports programs from discovery through preclinical and clinical development, the expertise spans multiple drug modalities, target classes, and therapeutic areas. Recently, Creative Bioarray has announced the launch of its cell angiogenesis assays, designed to accelerate the discovery and validation of anti-angiogenic therapies in oncology. The Angiogenesis Assay allows for the evaluation of pro- or anti-angiogenic effects of drugs on HUVEC sprouting capacity on a cellular basis. This exciting development underscores Creative Bioarray’s commitment to providing cutting-edge solutions that enhance research and drug development processes.
Angiogenesis, or the formation of new blood vessels, plays a critical role in tumor progression and metastasis, making it a significant target for cancer therapies. Beyond that, angiogenesis is necessary for tumor growth and is involved in other pathological disorders (e.g. psoriasis, macular degeneration). Creative Bioarray’s advanced multi-dimensional angiogenesis platforms utilize a combination of in vitro 3D co-culture models and validated in vivo assays to create a more physiological environment that better mimics human biology.
“By moving beyond the limitations of conventional models, we can provide researchers with high-quality, reproducible data that translates more reliably to clinical outcomes,” said Hannah Cole, the marketing director of Creative Bioarray. “Our angiogenesis assays allow for accelerated decision-making, from early screening to preclinical validation, providing critical insights that support the development of effective cancer therapies.”
The newly introduced assay suite includes three main in vitro platforms. Each of these assays has been meticulously designed to evaluate various aspects of angiogenesis:
HUVECs Tube Formation Assay: This rapid, quantitative assay assesses the formation of endothelial cell networks, utilizing primary human umbilical vein endothelial cells (HUVECs) on a basement membrane to recapitulate in vivo angiogenic processes.
- Spheroid Sprouting Assay: A 3D model that allows for the evaluation of endothelial spheroids embedded in collagen/Matrigel, measuring their ability to sprout and invade—a crucial factor in understanding tumor microenvironment interactions.
- Rat Aortic Ring Assay: This ex vivo model monitors microvessel outgrowth from primary aortic tissue, offering researchers high physiological relevance and insights into angiogenic sprouting.
- In addition to these in vitro assays, Creative Bioarray also offers ex vivo and in vivo platforms, including the Matrigel Plug Assay, CAM (Chick Chorioallantoic Membrane) Assay, and Corneal Angiogenesis Assay. These innovative models provide comprehensive profiles of compound effects on angiogenesis, enabling better selection and optimization of therapeutic candidates.
Creative Bioarray’s angiogenesis assay is a vessel sprouting assay that mimics the in vivo situation with respect to the first stages of the angiogenic cascade, (i) the sprouting in a 3D environment promotes cell-cell signaling between the endothelial cells, (ii) the surrounding matrix is degraded before the invasion, (iii) the spheroids used in the angiogenesis assay generate sprouts that are close to the physiological arrangement of endothelial cell vessels
“At Creative Bioarray, our goal is to bridge the gap between laboratory research and clinical application,” added Cole. “Our multi-tiered approach ensures that researchers have access to biologically relevant models that yield actionable insights in the battle against cancer.”
About Creative Bioarray
Creative Bioarray is a leading provider of high-quality life science research services and products, specializing in innovative solutions for drug discovery, cellular assays, and molecular biology. With a commitment to scientific excellence and customer satisfaction, Creative Bioarray supports the global research community with state-of-the-art technologies and robust scientific expertise.
Contact Info:
Name: Hannah Cole
Email: Send Email
Organization: Creative Bioarray
Address: Shirley, NY 11967, USA
Phone: 16313868241
Website: https://www.creative-bioarray.com/
Release ID: 89201005
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