Better U and Evernow have partnered to integrate menopause treatment with psychiatric care through telehealth. The collaboration addresses overlapping hormonal and psychological symptoms, including heightened depression risk during perimenopause. Partnership pricing, enrollment targets, and comparative clinical outcomes have not been disclosed.
Los Angeles, CA, California, United States, November 10, 2026 -- Women's healthcare providers Better U and Evernow have formed a telehealth partnership connecting specialized menopause treatment with psychiatric care, targeting the overlapping hormonal and psychological symptoms experienced by women during perimenopause and menopause.
Announced on September 30, 2026, the collaboration combines Evernow's menopause and hormone therapy services with Better U's integrative psychiatry, psychotherapy and mental wellness programs. Evernow operates across all 50 states, while Better U provides psychiatric treatment and other health services through its telehealth platform.
The Mental Health Burden of Menopause
Menopause is frequently associated with hot flashes and changes in menstrual cycles, but its psychological effects can be equally disruptive. According to The Menopause Society, up to 80% of women experience hot flashes during the menopause transition, with symptoms lasting an average of seven to 10 years. Sleep disturbances, anxiety and changes in mood can accompany these physical symptoms.
A 2024 systematic review and meta-analysis published in the Journal of Affective Disorders, examining 17 prospective studies involving 16,061 women, found that perimenopausal women had approximately 40% higher odds of experiencing depressive symptoms or receiving a depression diagnosis compared with premenopausal women. The findings reinforce the need to consider reproductive hormonal changes when evaluating mental health during midlife.
Connecting Hormonal Treatment With Psychiatry
The partnership brings together Dr. Ellamarie Russo-DeMara, Evernow's medical director and a board-certified obstetrician-gynecologist with more than 30 years of clinical experience, and Dr. Janette Leal, executive physician and medical director at Better U Clinical. Leal is a board-certified psychiatrist with additional training in internal medicine and geriatric psychiatry at Mayo Clinic.
Russo-DeMara, whose experience includes early menopause following chemotherapy for breast cancer, said the collaboration addresses gaps in how women receive treatment. "We've always believed menopause care should reach beyond hormones. Women in perimenopause and menopause are one of the most underserved populations in medicine, and too many are dismissed, misdiagnosed, or sent home with a prescription and no one ever looking at their hormones."
Leal emphasized the biological relationship between reproductive hormones and brain function. "Estrogen helps regulate serotonin and dopamine, and a progesterone byproduct called allopregnanolone acts on the same calming GABA receptors that help us sleep. When those hormones start to swing in perimenopause, the brain feels it."
Treatment Options and Clinical Considerations
Under the collaboration, women experiencing menopause-related symptoms may access hormonal treatment alongside psychiatric evaluation and psychological support. Better U also offers at-home ketamine therapy to selected patients experiencing depression or anxiety that has not responded adequately to previous treatment. The company states that patients undergo screening by licensed psychiatric clinicians before treatment is considered.
However, ketamine is not a treatment for menopause itself. The U.S. Food and Drug Administration has warned about risks associated with compounded ketamine for psychiatric conditions, including sedation, dissociation and potentially dangerous changes in blood pressure. Ketamine is not FDA-approved for psychiatric disorders, although the related medication esketamine has specific approved psychiatric indications under supervised administration.
Expanding Access While Measuring Outcomes
The collaboration reflects growing commercial interest in virtual menopause services, although combining mental health resources with menopause treatment is not entirely new. Evernow previously announced a partnership with Talkspace in December 2023 to expand access to mental health resources and menopause care.
Better U founder Derek Du Chesne framed the latest agreement around access to coordinated treatment. "Every woman deserves to be heard the first time she asks for help. I'm deeply grateful to partner with Evernow, Dr. Leal and Dr. Russo-DeMara to raise the standard of care by supporting mental and physical health together, and to bring that care to women wherever they live."
Russo-DeMara added: "Partnering with Better U lets us care for the whole woman, her hormones, her mood, her sleep and her sense of self, with a team that works together."
The companies have not disclosed patient enrollment targets, partnership pricing or comparative clinical outcome data for the combined services. Those details will be important in assessing whether the collaboration improves treatment continuity, symptom management and access beyond what patients can already obtain through separate menopause and mental health providers.
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